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Ectoine is a cyclic tetrahydropyrimidine organic osmolyte, which was discovered in the halophilic bacterium Ectothiorhodospira halochloris. It is the most abundant solute produced by aerobic heterotrophic eubacteria and has been extensively characterized as an osmoprotectant and stabilizer for cells and biomolecules.Ectoine is considered a member of the small molecule chaperones family (SMCs). SMCs accumulate to high intracellular concentrations, preventing the misfolding/ denaturation of proteins and other labile macromolecules.? Ectoine preserves enzymes and whole cells against harmful conditions such as freezing, drying, or heating. This molecule, among other compatible solutes, possesses the ability to conserve the proteolytic activity of trypsin and chymotrypsin. It has been shown to induce heat shock proteins and downregulate proinflammatory signals in human keratinocytes. It is not toxic to the cellular environment, even at concentrations as high as 100 mM.Ectoine strongly inhibits the Ab42 amyloid formation in vitro, reducing the toxicity to human neurblastoma cells. Ab42 was found to be the most predominant proteolytic fragment found in amyloid plaques, thus, ectoine may act as a potential inhibitor associated with neurodegenerative diseases.
Ectoine is a natural protector that stabilizes proteins and other cell structures and protects the skin from stresses such as UV exposure and dryness.
The CAS number of ECTOINE is 96702-03-3.
More information of ECTOINE 96702-03-3 are:
|
CAS Number |
96702-03-3 |
|
Density |
1.37g/cm3 |
|
Melting Point |
~280° |
|
Boiling Point |
381.5°Cat760mmHg |
|
Flash Point |
184.5°C |
|
Vapor Pressure |
7.09E-07mmHg at 25°C |
|
Refractive Index |
1.596 |
|
PSA |
61.69000 |
|
LogP |
-0.38430 |
|
Pka |
3.14±0.20(Predicted) |
The chemical formula of ECTOINE is C6H10 N2 O2 which containing 6 Carbon atoms,10 Hydrogen atoms,2 Nitrogen atoms and 2 Oxygen atoms,and the molecular weight, and the molecular weight of ECTOINE is 142.158
Ectoine is a cyclic tetrahydropyrimidine organic osmolyte, which was discovered in the halophilic bacterium Ectothiorhodospira halochloris. It is the most abundant solute produced by aerobic heterotrophic eubacteria and has been extensively characterized as an osmoprotectant and stabilizer for cells and biomolecules.Ectoine is considered a member of the small molecule chaperones family (SMCs). SMCs accumulate to high intracellular concentrations, preventing the misfolding/ denaturation of proteins and other labile macromolecules.? Ectoine preserves enzymes and whole cells against harmful conditions such as freezing, drying, or heating. This molecule, among other compatible solutes, possesses the ability to conserve the proteolytic activity of trypsin and chymotrypsin. It has been shown to induce heat shock proteins and downregulate proinflammatory signals in human keratinocytes. It is not toxic to the cellular environment, even at concentrations as high as 100 mM.Ectoine strongly inhibits the Ab42 amyloid formation in vitro, reducing the toxicity to human neurblastoma cells. Ab42 was found to be the most predominant proteolytic fragment found in amyloid plaques, thus, ectoine may act as a potential inhibitor associated with neurodegenerative diseases.
InChI:InChI=1/C6H10N2O2/c1-4-7-3-2-5(8-4)6(9)10/h5H,2-3H2,1H3,(H,7,8)(H,9,10)/t5-/m0/s1
Relevant articles related to ECTOINE:
|
Article |
Source |
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Identification of a Pyrrole Intermediate Which Undergoes C-Glycosidation and Autoxidation to Yield the Final Product in Showdomycin Biosynthesis |
Kim, Minje,Liu, Hung-wen,Ren, Daan,Wang, Shao-An , p. 17148 - 17154 (2021/06/28) |
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