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D(-)-Glutamic acid

  • ProductNo:537659-dc3b4978-9b37-48a8-aa42-90f375951d51
    Packing:
  • CasNo.:6893-26-1
    MW:147.131
  • Purity:>
    Content:
  • MF:C5H9NO4
    Apply:

99% Purity Commercial production D(-)-Glutamic acid 6893-26-1 with Cheapest Price

  • Molecular Formula:C5H9NO4
  • Molecular Weight:147.131
  • Appearance/Colour:white crystalline powder 
  • Vapor Pressure:2.55E-05mmHg at 25°C 
  • Melting Point:200-202 °C 
  • Refractive Index:1.4210 (estimate) 
  • Boiling Point:333.8 °C at 760 mmHg 
  • PKA:pK1:2.162(+1);pK2:4.272(0);pK3:9.358(-1) (25°C) 
  • Flash Point:155.7 °C 
  • PSA:100.62000 
  • Density:1.409 g/cm3 
  • LogP:-0.03660 

D(-)-Glutamic acid(Cas 6893-26-1) Usage

Biological Activity

Excitatory amino acid acting at NMDA receptors; less active than the L-isomer.

Biochem/physiol Actions

Unnatural isomer of glutamic acid.

General Description

D(-)-Glutamic acid, also known as D-Glutamate or (R)-2-aminopentanedioic acid, is a stereoisomer of glutamic acid that serves as a key substrate or mimetic in the design of inhibitors targeting the D-glutamic acid-adding enzyme (MurD). Its rigidified analogues have been explored to enhance binding affinity and inhibitory activity against MurD, a critical enzyme in bacterial cell wall biosynthesis, demonstrating its relevance in the development of novel antibacterial agents.

Definition

ChEBI: An optically active form of glutamic acid having D-configuration.

InChI:InChI=1/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m1/s1

6893-26-1 Relevant articles

Noncovalently Functionalized Commodity Polymers as Tailor-Made Additives for Stereoselective Crystallization

Wan, Xinhua,Wang, Zhaoxu,Ye, Xichong,Zhang, Jie

supporting information, p. 20243 - 20248 (2021/08/09)

Stereoselective inhibition of the nuclea...

Highly selective synthesis of d-amino acids from readily available l-amino acids by a one-pot biocatalytic stereoinversion cascade

Zhang, Danping,Jing, Xiaoran,Zhang, Wenli,Nie, Yao,Xu, Yan

, p. 29927 - 29935 (2019/10/01)

d-Amino acids are key intermediates requ...

Preparation and characterization of a new open-tubular capillary column for enantioseparation by capillary electrochromatography

Li, Yingjie,Tang, Yimin,Qin, Shili,Li, Xue,Dai, Qiang,Gao, Lidi

, p. 283 - 292 (2019/02/05)

In order to use the enantioseparation ca...

Artificial Biocatalytic Cascade with Three Enzymes in One Pot for Asymmetric Synthesis of Chiral Unnatural Amino Acids

Zhou, Haisheng,Meng, Lijun,Yin, Xinjian,Liu, Yayun,Xu, Gang,Wu, Jianping,Wu, Mianbin,Yang, Lirong

, p. 6470 - 6477 (2019/11/02)

Two biocatalytic reactions, transaminati...

6893-26-1 Process route

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D-glutamic acid γ-p-nitroanilide

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4-nitro-aniline
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4-nitro-aniline

Conditions
Conditions Yield
With marine bivalve lysozyme; MOPS buffer; Tapes japonica; at 37 ℃; pH=7.0; Enzyme kinetics;
α-ketoglutaric acid
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α-ketoglutaric acid

D-norvaline
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2-oxopentanoic acid
1821-02-9

2-oxopentanoic acid

Conditions
Conditions Yield
With pyridoxal 5'-phosphate; recombinant Lactobacillus salivarius UCC118 D-amino acid aminotransferase; In aq. phosphate buffer; at 30 ℃; for 0.0166667h; pH=7.5; Enzymatic reaction;

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