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Biological Activity |
Excitatory amino acid acting at NMDA receptors; less active than the L-isomer. |
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Biochem/physiol Actions |
Unnatural isomer of glutamic acid. |
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General Description |
D(-)-Glutamic acid, also known as D-Glutamate or (R)-2-aminopentanedioic acid, is a stereoisomer of glutamic acid that serves as a key substrate or mimetic in the design of inhibitors targeting the D-glutamic acid-adding enzyme (MurD). Its rigidified analogues have been explored to enhance binding affinity and inhibitory activity against MurD, a critical enzyme in bacterial cell wall biosynthesis, demonstrating its relevance in the development of novel antibacterial agents. |
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Definition |
ChEBI: An optically active form of glutamic acid having D-configuration. |
InChI:InChI=1/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m1/s1
Stereoselective inhibition of the nuclea...
d-Amino acids are key intermediates requ...
In order to use the enantioseparation ca...
Two biocatalytic reactions, transaminati...
D-glutamic acid γ-p-nitroanilide
D-Glutamic acid
4-nitro-aniline
| Conditions | Yield |
|---|---|
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With
marine bivalve lysozyme; MOPS buffer; Tapes japonica;
at 37 ℃;
pH=7.0;
Enzyme kinetics;
|
α-ketoglutaric acid
D-norvaline
D-Glutamic acid
2-oxopentanoic acid
| Conditions | Yield |
|---|---|
|
With
pyridoxal 5'-phosphate; recombinant Lactobacillus salivarius UCC118 D-amino acid aminotransferase;
In
aq. phosphate buffer;
at 30 ℃;
for 0.0166667h;
pH=7.5;
Enzymatic reaction;
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Glutamic acid
Acetyl-D,L-glutaminsaeure
N-benzoylglutamic acid
N-benzyloxycarbonyl-DL-glutamic acid
(R)-2-amino-5-methoxy-5-oxopentanoic acid
methyl 5-oxopyrrolidine-2-carboxylate
N-phthaloyl-D-glutamic acid anhydride
N-(4-nicotinoylamino-benzoyl)-D-glutamic acid