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Chemical Description |
Histidine is an alpha-amino acid containing an isopyrazole ring. It is a constituent amino acid of body proteins and is found in some functional proteins such as histones and hemoglobin. |
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Physiological Functions |
Histidine is a natural chelating agent and is involved in the structure and function of many enzymes. |
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Molecular Interactions |
The versatility of histidine in molecular interactions arises from its unique molecular structure. Histidine's imidazole side chain can engage in various molecular interactions, including cation-π interaction, π-π stacking interaction, hydrogen-π interaction, coordinate bond interaction, and hydrogen bond interaction. These interactions contribute to histidine's role in protein structure, enzymatic function, and other physiological processes. |
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Nutritional and Therapeutic Uses |
Histidine is considered an essential amino acid for young children but non-essential for adults. It has been used as a nutritional supplement in various conditions such as rheumatoid arthritis, anaemia in chronic renal failure, fatigue during exercise, ageing-related disorders, metabolic syndrome, atopic dermatitis, ulcers, inflammatory bowel diseases, ocular diseases, and neurological disorders. |
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General Description |
Histidine is an essential amino acid that is crucial for the synthesis of proteins in the human body. It plays a key role in the growth and repair of tissues, as well as in the maintenance of the myelin sheath that protects nerve cells. Additionally, histidine is a precursor for the synthesis of histamine, which is involved in various physiological processes such as digestion, immune response, and inflammation. It also acts as a metal chelator, binding with heavy metals to aid in their excretion from the body. Histidine is found in various protein-rich foods such as meat, fish, dairy products, and certain grains, making it an important nutrient for overall health and well-being. |
InChI:InChI:1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)
An unusual trans cleavage reaction was o...
Asymmetric transformation reaction of L-...
Amino acids are key synthetic building b...
Strategic replacement of protons with fl...
Described are methods and compositions f...
l-Carnosine (l-Car, β-alanyl-l-histidine...
Hizikia fusiformis lectine
L-alanin
L-Cysteine
L-threonine
L-leucine
L-isoleucine
L-methionine
L-lysine
L-glutamic acid
L-arginine
L-phenylalanine
L-tyrosine
L-proline
L-histidine
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride;
In
water;
at 100 ℃;
for 24h;
Inert atmosphere;
Sealed tube;
|
type I collagen from Bester sturgeon scales
L-alanin
L-valine
L-serin
L-threonine
L-leucine
L-isoleucine
L-methionine
L-lysine
L-Aspartic acid
(5R)-5-hydroxy-L-lysine
L-arginine
S,S-cystine
L-phenylalanine
L-tyrosine
glycine
L-proline
4R-4-hydroxyproline
L-histidine
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride; water;
at 110 ℃;
for 24h;
|
ammonia
2-chloro-3-(1H-imidazol-4-yl)propanoic acid
sulfuric acid
Carnosine
Nα-formyl-histidine
1,Nα-dipicryl-histidine
4-cyanomethylimidazole
1H-imidazole